Human Genome Dayton OH

Scientists hope to learn the actual names and sequences of all 3 billion nitrogenous bases in the human genome. Automation and computerization are essential tools in the sequencing, and the development of the specific technology is underway.

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Iya Technology Laboratory Inc
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In 1990, researchers at Celera Genomics and at the National Human Genome Research Institute began an ambitious endeavor to sequence the entire human genome. In 2000, researchers revealed to the general public that a substantial portion of this work had been completed. This “rough draft” of the human genome is currently in fragments much like pieces of a jigsaw puzzle. Current efforts are underway to match the different pieces to complete the puzzle. Recently, Celera Genomics revealed their startling estimation of the number of human genes to be 30,000. This estimation, based on the sequence data, is substantially below previous predictions. The sequence data has led to the estimation that less than 5% of the human genome actually encodes functional proteins. Once the jigsaw puzzle is completed, the data will undoubtedly help researchers devise new diagnostics and treatments for genetic diseases.

In addition to sequencing the human genome, researchers have sequenced the genomes of Drosophila melanogaster (fruit fly), Arabidopsis thaliana (plant), Saccharomyces cerevisiae (budding yeast), and C. elegans (worm). In addition, mouse, rat, and zebrafish genomes have been sequenced. Not only eukaryotic organisms are useful to the research community. The genome of Plasmodium (the organism that causes malaria) has also been sequenced. The goals of these sequencing projects are to prepare gene linkage maps and physical maps. A gene linkage map is a map that pinpoints the location of genes based on their connection to certain marker gene sequences. A physical map, in comparison, gives the actual number of bases between genes on a chromosome; therefore, it locates the gene of interest more precisely.

Ultimately, scientists hope to learn the actual names and sequences of all 3 billion nitrogenous bases in the human genome. Automation and computerization are essential tools in the sequencing, and the development of the specific technology is underway.

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